01822nas a2200133   4500008004100000020001400041245010900055210006900164260001200233300001400245490000800259520138100267856004001648       2000                        eng d  a0033-841900aMultiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter0 aMultiple sclerosis Magnetization transfer histogram analysis of   c2000///  a351 - 3550 v2163 aPURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
  uhttps://inf.u-szeged.hu/en/node/99401615nas a2200133   4500008004100000020001400041245009600055210006900151260001200220300001400232490000700246520118700253856004101440       2000                        eng d  a1053-180700aNumerical tissue characterization in MS via standardization of the MR image intensity scale0 aNumerical tissue characterization in MS via standardization of t  c2000///  a715 - 7210 v123 aImage intensity standardization is a recently developedpostprocessing method that is capable of correcting the signal 
intensity variations in MR images. We evaluated signal intensity 
of healthy and diseased tissues in 10 multiple sclerosis (MS) 
patients based on standardized dual fast spin-echo MR images 
using a numerical postprocessing technique. The main idea of 
this technique is to deform the volume image histogram of each 
study to match a standard histogram and to utilize the resulting 
transformation to map the image intensities into standard scale. 
Upon standardization, the coefficients of variation of signal 
intensities for each segmented tissue (gray matter, white 
matter, lesion plaques, and diffuse abnormal white matter) in 
all patients were significantly smaller (2.3-9.2 times) than in 
the original images, and the same tissues from different 
patients looked alike, with similar intensity characteristics. 
Numerical tissue characterizability of different tissues in MS 
achieved by standardization offers a fixed tissue-specific 
meaning for the numerical values and can significantly 
facilitate image segmentation and analysis.
  uhttps://inf.u-szeged.hu/en/node/100300376nas a2200097   4500008004100000245009600041210006900137260002300206300000800229856004100237       2000                        eng d00aNumerical Tissue Characterization in MS via Standardization of the MR Image Intensity Scale0 aNumerical Tissue Characterization in MS via Standardization of t  aBerkeleycApr 2000  a579  uhttps://inf.u-szeged.hu/en/node/101900361nas a2200085   4500008004100000245011200041210006900153260001200222856004100234       1999                        eng d00aMagnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis0 aMagnetization Transfer Histogram Analysis of Segmented Normal Ap  c1999///  uhttps://inf.u-szeged.hu/en/node/107200391nas a2200097   4500008004100000245011100041210006900152260002300221300000800244856004100252       1999                        eng d00aMagnetization Transfer Histogram Analysis of Segmented Normal-Appearing White Matter in Multiple Sclerosis0 aMagnetization Transfer Histogram Analysis of Segmented NormalApp  aBerkeleycMay 1999  a957  uhttps://inf.u-szeged.hu/en/node/102000345nas a2200085   4500008004100000245009600041210006900137260001200206856004100218       1999                        eng d00aNumerical Tissue Characterization in MS via Standardization of the MR Image Intensity Scale0 aNumerical Tissue Characterization in MS via Standardization of t  c1999///  uhttps://inf.u-szeged.hu/en/node/1073