01649nas a2200133   4500008004100000020001400041245012400055210006900179260001200248300001400260490000800274520119200282856004101474       2001                        eng d  a0033-841900aBrain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter0 aBrain atrophy in relapsingremitting multiple sclerosis Fractiona  c2001///  a606 - 6100 v2203 aPURPOSE: To determine the fractional brain tissue volume changesin the gray matter and white matter of patients with relapsing-
remitting multiple sclerosis (MS) and to correlate these 
measurements with clinical disability and total lesion load. 
MATERIALS AND METHODS: Thirty patients with relapsing-remitting 
MS and 25 healthy control subjects underwent magnetic resonance 
imaging. Fractional brain tissue volumes (tissue volume relative 
to total intracranial volume) were obtained from the total 
segmented gray matter and white matter in each group and were 
analyzed. RESULTS: The fractional volume of white matter versus 
that of gray matter was significantly lower (-6.4%) in patients 
with MS (P <.0001) than in control subjects. Neither gray matter 
nor white matter fractional volume measurements correlated with 
clinical disability in the patients with MS. CONCLUSION: Loss of 
brain parenchymal volume in patients with relapsing-remitting MS 
is predominantly confined to white matter. Analysis of 
fractional brain tissue volumes provides additional information 
useful in characterizing MS and may have potential in evaluating 
treatment strategies.
  uhttps://inf.u-szeged.hu/en/node/100400375nas a2200085   4500008004100000245012600041210006900167260001200236856004100248       2000                        eng d00aBrain Atrophy in Relapsing-Remitting Multiple Sclerosis: A Fractional Volumetric Analysis of Gray Matter and White Matter0 aBrain Atrophy in RelapsingRemitting Multiple Sclerosis A Fractio  c2000///  uhttps://inf.u-szeged.hu/en/node/107600356nas a2200085   4500008004100000245010700041210006900148260001200217856004100229       2000                        eng d00aMagnetization Transfer Ratio Histogram Analysis of Normal Appearing Gray Matter and White Matter in MS0 aMagnetization Transfer Ratio Histogram Analysis of Normal Appear  c2000///  uhttps://inf.u-szeged.hu/en/node/107401822nas a2200133   4500008004100000020001400041245010900055210006900164260001200233300001400245490000800259520138100267856004001648       2000                        eng d  a0033-841900aMultiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter0 aMultiple sclerosis Magnetization transfer histogram analysis of   c2000///  a351 - 3550 v2163 aPURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
  uhttps://inf.u-szeged.hu/en/node/99400361nas a2200085   4500008004100000245011200041210006900153260001200222856004100234       1999                        eng d00aMagnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis0 aMagnetization Transfer Histogram Analysis of Segmented Normal Ap  c1999///  uhttps://inf.u-szeged.hu/en/node/107200391nas a2200097   4500008004100000245011100041210006900152260002300221300000800244856004100252       1999                        eng d00aMagnetization Transfer Histogram Analysis of Segmented Normal-Appearing White Matter in Multiple Sclerosis0 aMagnetization Transfer Histogram Analysis of Segmented NormalApp  aBerkeleycMay 1999  a957  uhttps://inf.u-szeged.hu/en/node/1020