@article {994,
	title = {Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter},
	journal = {RADIOLOGY},
	volume = {216},
	year = {2000},
	note = {UT: 000088430800008ScopusID: 0033894599},
	month = {2000///},
	pages = {351 - 355},
	abstract = {PURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5\% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
},
	isbn = {0033-8419}
}
@booklet {1072,
	title = {Magnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis},
	year = {1999},
	month = {1999///}
}
@conference {1020,
	title = {Magnetization Transfer Histogram Analysis of Segmented Normal-Appearing White Matter in Multiple Sclerosis},
	booktitle = {International Society for Magnetic Resonance in Medicine: Seventh Scientific Meeting and Exhibition},
	year = {1999},
	month = {May 1999},
	pages = {957},
	address = {Berkeley}
}
