@inbook {1047,
	title = {Appearance-based Approach to Extract an Age-related Biomarker from Retinal Images},
	booktitle = {3rd Russian-Bavarian Conference on Bio-Medical Engineering, Proceedings},
	volume = {1},
	year = {2007},
	month = {2007},
	pages = {127 - 131},
	publisher = {Friedrich-Alexander University Erlangen-Nuremberg},
	organization = {Friedrich-Alexander University Erlangen-Nuremberg},
	type = {Conference paper},
	address = {Erlangen},
	abstract = {<p>We present an appearance-based method that extracts a new age-related biomarker from retina images. The Principal Component Analysis is applied on intensity values of the illumination corrected green channel of fundus images. The algorithm does not use segmentation, is robust and shows a high range of reliability. It identified an age-related feature with a strong influence of the temporal parapapillary area and the optic nerve head. The feature correlates with chronological age of the participants and is significantly influenced by the appearance of cardiovascular risk factors such as smoking and hypertension, and thus it can be designated a biomarker. We extract and validate a medical parameter from retina images applying a purely data-driven approach without using any prior knowledge.</p>},
	author = {Rudriger Bock and J{\"o}rg Meier and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Simone W{\"a}rntges and Georg Michelson and Joachim Hornegger},
	editor = {Joachim Hornegger and Ernst W Mayr and Sergey Schookin and Hubertus Feu{\ss}ner and Nassir Navab and Yuri V. Gulyaev and Kurt H{\"o}ller and Victor Ganzha}
}
